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Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation

More than half of human tumors harbor an inactivated p53 tumor-suppressor gene. It is well accepted that mutant p53 shows an oncogenic gain-of-function (GOF) activity that facilitates the transformed phenotype of cancer cells. In addition, a growing body of evidence supports the notion that cancer s...

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Vydáno v:Cold Spring Harb Perspect Med
Hlavní autoři: Shetzer, Yoav, Molchadsky, Alina, Rotter, Varda
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046690/
https://ncbi.nlm.nih.gov/pubmed/27235476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026203
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