Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

The tumour suppressor p53 plays an important role in somatic cell reprogramming. While wild-type p53 reduces reprogramming efficiency, mutant p53 exerts a gain of function activity that leads to increased reprogramming efficiency. Furthermore, induced pluripotent stem cells expressing mutant p53 los...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Grespi, Francesca, Landré, Vivien, Molchadsky, Alina, Di Daniele, Nicola, Marsella, Luigi Tonino, Melino, Gerry, Rotter, Varda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260988/
https://ncbi.nlm.nih.gov/pubmed/28032868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.419
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