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Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells
p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent state. As p53 is usually mutated in human tumors and many mutated forms of p53 gain novel activities, we studied the influence of mutant p53 (mut-p53) on somatic cell reprogramming. Our data indicate a novel gain o...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947075/ https://ncbi.nlm.nih.gov/pubmed/20696700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100797 |
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