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Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides
The p53 tumor suppressor serves as a major barrier against malignant transformation. Over 50% of tumors inactivate p53 by point mutations in its DNA binding domain. Most mutations destabilize p53 protein folding, causing its partial denaturation at physiological temperature. Thus a high proportion o...
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| Publicado no: | Oncotarget |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914250/ https://ncbi.nlm.nih.gov/pubmed/26943582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7857 |
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