Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

The present study examined whether the ability of mutant p53 to block apoptosis depended on its transcriptional activity. A core domain mutant p53 (143 Val to Ala), in which two N-terminal residues (22 and 23) essential for transactivation were also mutated (Leu to Glu and Trp to Ser, respectively),...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Matas, Devorah, Sigal, Alex, Stambolsky, Perry, Milyavsky, Michael, Weisz, Lilach, Schwartz, Dov, Goldfinger, Naomi, Rotter, Varda
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483519/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.4163
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