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Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis
The present study examined whether the ability of mutant p53 to block apoptosis depended on its transcriptional activity. A core domain mutant p53 (143 Val to Ala), in which two N-terminal residues (22 and 23) essential for transactivation were also mutated (Leu to Glu and Trp to Ser, respectively),...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149170/ https://ncbi.nlm.nih.gov/pubmed/11483519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.15.4163 |
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