Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

The p53 tumor suppressor serves as a major barrier against malignant transformation. Over 50% of tumors inactivate p53 by point mutations in its DNA binding domain. Most mutations destabilize p53 protein folding, causing its partial denaturation at physiological temperature. Thus a high proportion o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Tal, Perry, Eizenberger, Shay, Cohen, Elad, Goldfinger, Naomi, Pietrokovski, Shmuel, Oren, Moshe, Rotter, Varda
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Priority Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914250/
https://ncbi.nlm.nih.gov/pubmed/26943582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7857
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