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Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent, novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function (GOF). A growing body of evidence suggests that th...
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| Veröffentlicht in: | Int J Mol Sci |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6940767/ https://ncbi.nlm.nih.gov/pubmed/31817996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20246197 |
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