Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously,...

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Hlavní autoři: Tanaka, Mari, Asada, Misako, Higashi, Atsuko Y., Nakamura, Jin, Oguchi, Akiko, Tomita, Mayumi, Yamada, Sachiko, Asada, Nariaki, Takase, Masayuki, Okuda, Tomohiko, Kawachi, Hiroshi, Economides, Aris N., Robertson, Elizabeth, Takahashi, Satoru, Sakurai, Takeshi, Goldschmeding, Roel, Muso, Eri, Fukatsu, Atsushi, Kita, Toru, Yanagita, Motoko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827946/
https://ncbi.nlm.nih.gov/pubmed/20197625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39569
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