Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously,...

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主要な著者: Tanaka, Mari, Asada, Misako, Higashi, Atsuko Y., Nakamura, Jin, Oguchi, Akiko, Tomita, Mayumi, Yamada, Sachiko, Asada, Nariaki, Takase, Masayuki, Okuda, Tomohiko, Kawachi, Hiroshi, Economides, Aris N., Robertson, Elizabeth, Takahashi, Satoru, Sakurai, Takeshi, Goldschmeding, Roel, Muso, Eri, Fukatsu, Atsushi, Kita, Toru, Yanagita, Motoko
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2010
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827946/
https://ncbi.nlm.nih.gov/pubmed/20197625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39569
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