Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously,...

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Main Authors: Tanaka, Mari, Asada, Misako, Higashi, Atsuko Y., Nakamura, Jin, Oguchi, Akiko, Tomita, Mayumi, Yamada, Sachiko, Asada, Nariaki, Takase, Masayuki, Okuda, Tomohiko, Kawachi, Hiroshi, Economides, Aris N., Robertson, Elizabeth, Takahashi, Satoru, Sakurai, Takeshi, Goldschmeding, Roel, Muso, Eri, Fukatsu, Atsushi, Kita, Toru, Yanagita, Motoko
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2010
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Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827946/
https://ncbi.nlm.nih.gov/pubmed/20197625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39569
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