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A Macrophage Cell Model for Selective Metalloprotein Inhibitor Design
The desire to inhibit zinc-dependent matrix metalloproteinases (MMPs) has lead to the development of a plethora of MMP inhibitors over the course of the last 30 years that bind directly to the active site metal. With the exception of one inhibitor, all of these drugs have failed in clinical trials d...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826882/ https://ncbi.nlm.nih.gov/pubmed/18666306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800148 |
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