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Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29–43% for five matrix metalloproteases (MMPs), 24% for anthrax lethal facto...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024453/ https://ncbi.nlm.nih.gov/pubmed/21189019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101266s |
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