Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29–43% for five matrix metalloproteases (MMPs), 24% for anthrax lethal facto...

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Bibliographic Details
Main Authors: Jacobsen, Jennifer A., Fullagar, Jessica, Miller, Melissa T., Cohen, Seth M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024453/
https://ncbi.nlm.nih.gov/pubmed/21189019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101266s
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