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Investigating Chelating Sulfonamides and their use in Metalloproteinase Inhibitors
Matrix metalloproteinase inhibitors (MMPi) utilize zinc-binding groups (ZBGs) to chelate the catalytic Zn(II) ion resulting in enzyme inhibition. Adapting findings from the literature of Zn(II) ion sensors, we previously reported chelating sulfonamide inhibitors of MMP-2, some of which showed excell...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685695/ https://ncbi.nlm.nih.gov/pubmed/22411188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2dt12373h |
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