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Investigating Chelating Sulfonamides and their use in Metalloproteinase Inhibitors
Matrix metalloproteinase inhibitors (MMPi) utilize zinc-binding groups (ZBGs) to chelate the catalytic Zn(II) ion resulting in enzyme inhibition. Adapting findings from the literature of Zn(II) ion sensors, we previously reported chelating sulfonamide inhibitors of MMP-2, some of which showed excell...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685695/ https://ncbi.nlm.nih.gov/pubmed/22411188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2dt12373h |
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