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Investigating the Selectivity of Metalloenzyme Inhibitors in the Presence of Competing Metalloproteins

Metalloprotein inhibitors (MPi) are an important class of therapeutics for the treatment of a variety of diseases, including hypertension, cancer, and HIV/AIDS. However, despite their clinical success, there is an apprehension that MPi may be less selective than other small molecule therapeutics, an...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Chen, Yao, Cohen, Seth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658394/
https://ncbi.nlm.nih.gov/pubmed/26412596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500293
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