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Metal-Binding Isosteres as New Scaffolds for Metalloenzyme Inhibitors
The principle of isosteres or bioisosteres in medicinal chemistry is a central and essential concept in modern drug discovery. For example, carboxylic acids are often replaced by bioisosteres to mitigate issues related to lipophilicity or acidity, while retaining acidic characteristics in addition t...
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| Publicado no: | Inorg Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6289299/ https://ncbi.nlm.nih.gov/pubmed/30009599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.8b01632 |
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