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(19)F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes
This study demonstrates the screening of a collection of twelve (19)F-tagged metal-binding pharmacophores (MBPs) against the Zn(II)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by (19)F NMR. The isomorphous replacement of Zn(II) by Co(II) in hCAII produces enhanced sensitivity and rev...
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| Publicado en: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8137660/ https://ncbi.nlm.nih.gov/pubmed/33870988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01231b |
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