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Isosteres of Hydroxypyridinethione as Druglike Pharmacophores for Metalloenzyme Inhibition
Hydroxypyridine thiones (HOPTOs) are strong ligands for metal ions and are therefore potentially useful pharmacophores for inhibiting metalloenzymes relevant to human disease. However, HOPTOs have been sparingly used in drug discovery efforts due, in part, to concerns that this scaffold will act as...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Biol Inorg Chem |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6330162/ https://ncbi.nlm.nih.gov/pubmed/30003339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1593-1 |
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