Gamma Interferon Signaling in Oligodendrocytes Is Critical for Protection from Neurotropic Coronavirus Infection

Neurotropic coronavirus induces acute encephalomyelitis and demyelination in mice. Infection of BALB/c (H-2(d)) mice expressing a dominant negative gamma interferon (IFN-γ) receptor specifically in oligodendrocytes was examined to determine the influence of IFN-γ signaling on pathogenesis. Inhibitio...

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Detalles Bibliográficos
Main Authors: Parra, Gabriel I., Bergmann, Cornelia C., Phares, Timothy W., Hinton, David R., Atkinson, Roscoe, Stohlman, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826048/
https://ncbi.nlm.nih.gov/pubmed/20042510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02373-09
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