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Perforin and Gamma Interferon-Mediated Control of Coronavirus Central Nervous System Infection by CD8 T Cells in the Absence of CD4 T Cells

Infection of the central nervous system (CNS) with the neurotropic JHM strain of mouse hepatitis virus produces acute and chronic demyelination. The contributions of perforin-mediated cytolysis and gamma interferon (IFN-γ) secretion by CD8(+) T cells to the control of infection and the induction of...

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Autors principals: Bergmann, Cornelia C., Parra, Beatriz, Hinton, David R., Ramakrishna, Chandran, Dowdell, Konechi C., Stohlman, Stephen A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC369505/
https://ncbi.nlm.nih.gov/pubmed/14747539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.1739-1750.2004
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