Perforin and Gamma Interferon-Mediated Control of Coronavirus Central Nervous System Infection by CD8 T Cells in the Absence of CD4 T Cells

Infection of the central nervous system (CNS) with the neurotropic JHM strain of mouse hepatitis virus produces acute and chronic demyelination. The contributions of perforin-mediated cytolysis and gamma interferon (IFN-γ) secretion by CD8(+) T cells to the control of infection and the induction of...

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Pubblicato in:	J Virol
Autori principali:	Bergmann, Cornelia C., Parra, Beatriz, Hinton, David R., Ramakrishna, Chandran, Dowdell, Konechi C., Stohlman, Stephen A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14747539/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.4.1739-1750.2004
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