Protective Immunity to Rotavirus Shedding in the Absence of Interleukin-6: Th1 Cells and Immunoglobulin A Develop Normally

We investigated whether interleukin-6 (IL-6) was required for the development of immunoglobulin A (IgA)- and T-helper 1 (Th1)-associated protective immune responses to rotavirus by using adult IL-6-deficient mice [BALB/c and (C57BL/6 × O1a)F(2) backgrounds]. Naive IL-6(−) mice had normal frequencies...

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Main Authors: VanCott, John L., Franco, Manuel A., Greenberg, Harry B., Sabbaj, Steffanie, Tang, Baozhing, Murray, Richard, McGhee, Jerry R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110879/
https://ncbi.nlm.nih.gov/pubmed/10799601
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