CD4 T Cells Contribute to Virus Control and Pathology following Central Nervous System Infection with Neurotropic Mouse Hepatitis Virus

Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-γ) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contribut...

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Bibliografiske detaljer
Main Authors: Stohlman, Stephen A., Hinton, David R., Parra, Beatriz, Atkinson, Roscoe, Bergmann, Cornelia C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258904/
https://ncbi.nlm.nih.gov/pubmed/18094171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01762-07
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