Ifit2 Deficiency Results in Uncontrolled Neurotropic Coronavirus Replication and Enhanced Encephalitis via Impaired Alpha/Beta Interferon Induction in Macrophages

Type I interferons (IFN-α/β) limit viral dissemination prior to the emergence of adaptive immune responses through the concerted action of interferon-stimulated genes (ISGs). Although IFN-α/β induction by coronaviruses is modest, it effectively limits viral spread within the central nervous system (...

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Main Authors: Butchi, Niranjan B., Hinton, David R., Stohlman, Stephen A., Kapil, Parul, Fensterl, Volker, Sen, Ganes C., Bergmann, Cornelia C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Pathogenesis and Immunity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911674/
https://ncbi.nlm.nih.gov/pubmed/24198415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02272-13
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