1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to be active in at least patients infected with HCV o...

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Main Authors: Nyanguile, Origène, Devogelaere, Benoit, Vijgen, Leen, Van den Broeck, Walter, Pauwels, Frederik, Cummings, Maxwell D., De Bondt, Hendrik L., Vos, Ann M., Berke, Jan M., Lenz, Oliver, Vandercruyssen, Geneviève, Vermeiren, Katrien, Mostmans, Wendy, Dehertogh, Pascale, Delouvroy, Frédéric, Vendeville, Sandrine, VanDyck, Koen, Dockx, Koen, Cleiren, Erna, Raboisson, Pierre, Simmen, Kenneth A., Fanning, Gregory C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826027/
https://ncbi.nlm.nih.gov/pubmed/20071590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01980-09
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