Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

The search for hepatitis C virus polymerase inhibitors has resulted in the identification of several nonnucleoside binding pockets. The shape and nature of these binding sites differ across and even within diverse hepatitis C virus genotypes. These differences confront antiviral drug discovery with...

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Autori principali: Pauwels, Frederik, Mostmans, Wendy, Quirynen, Ludo M. M., van der Helm, Liesbet, Boutton, Carlo W., Rueff, Anne-Stéphanie, Cleiren, Erna, Raboisson, Pierre, Surleraux, Dominique, Nyanguile, Origène, Simmen, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933266/
https://ncbi.nlm.nih.gov/pubmed/17459932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01543-06
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