1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we report the discovery of a novel class of HCV polym...

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Bibliographic Details
Main Authors: Nyanguile, Origène, Pauwels, Frederik, Van den Broeck, Walter, Boutton, Carlo W., Quirynen, Ludo, Ivens, Tania, van der Helm, Liesbet, Vandercruyssen, Geneviève, Mostmans, Wendy, Delouvroy, Frédéric, Dehertogh, Pascale, Cummings, Maxwell D., Bonfanti, Jean-Francois, Simmen, Kenneth A., Raboisson, Pierre
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592889/
https://ncbi.nlm.nih.gov/pubmed/18852280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00669-08
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