Intranasal Vaccinations with the trans-Sialidase Antigen plus CpG Adjuvant Induce Mucosal Immunity Protective against Conjunctival Trypanosoma cruzi Challenges

Trypanosoma cruzi is an intracellular protozoan parasite capable of infecting through mucosal surfaces. Our laboratory has previously elucidated the anatomical routes of infection after both conjunctival and gastric challenge in mice. We have shown that chronically infected mice develop strong immun...

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Bibliographic Details
Main Authors: Giddings, O. K., Eickhoff, C. S., Sullivan, N. L., Hoft, D. F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825935/
https://ncbi.nlm.nih.gov/pubmed/20048046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00278-09
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