Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout

Alterations in trans-sarcolemmal and sarcoplasmic reticulum (SR) Ca(2+) fluxes may contribute to impaired cardiomyocyte contraction and relaxation in heart failure. We investigated the mechanisms underlying heart failure progression in mice with conditional, cardiomyocyte-specific excision of the SR...

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Detalhes bibliográficos
Main Authors: Louch, William E, Hougen, Karina, Mørk, Halvor K, Swift, Fredrik, Aronsen, Jan M, Sjaastad, Ivar, Reims, Henrik M, Roald, Borghild, Andersson, Kristin B, Christensen, Geir, Sejersted, Ole M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825611/
https://ncbi.nlm.nih.gov/pubmed/20008467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.183517
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