Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A(2) Expression: A ROLE FOR REGULATION BY SREBP-1

Our recent studies indicate that endoplasmic reticulum (ER) stress causes INS-1 cell apoptosis by a Ca(2+)-independent phospholipase A(2) (iPLA(2)β)-mediated mechanism that promotes ceramide generation via sphingomyelin hydrolysis and subsequent activation of the intrinsic pathway. To elucidate the...

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Bibliographic Details
Main Authors: Lei, Xiaoyong, Zhang, Sheng, Barbour, Suzanne E., Bohrer, Alan, Ford, Eric L., Koizumi, Akio, Papa, Feroz R., Ramanadham, Sasanka
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825464/
https://ncbi.nlm.nih.gov/pubmed/20032468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084293
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