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Endoplasmic Reticulum Stress, Pancreatic β-Cell Degeneration, and Diabetes
Overwhelming of protein folding in the endoplasmic reticulum (ER)—referred to as “ER stress”—activates a set of intracellular signaling pathways termed the unfolded protein response (UPR). Beneficial outputs of the UPR promote adaptation in cells experiencing manageably low levels of ER stress. Howe...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426819/ https://ncbi.nlm.nih.gov/pubmed/22951443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a007666 |
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