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Calcium-independent Phospholipase A(2) (iPLA(2)β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis
Endoplasmic reticulum (ER) stress induces INS-1 cell apoptosis by a pathway involving Ca(2+)-independent phospholipase A(2) (iPLA(2)β)-mediated ceramide generation, but the mechanism by which iPLA(2)β and ceramides contribute to apoptosis is not well understood. We report here that both caspase-12 a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596401/ https://ncbi.nlm.nih.gov/pubmed/18936091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807409200 |
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