THE GROUP VIA CALCIUM-INDEPENDENT PHOSPHOLIPASE A(2) (iPLA(2)β) PARTICIPATES IN ER STRESS-INDUCED INS-1 INSULINOMA CELL APOPTOSIS BY PROMOTING CERAMIDE GENERATION VIA HYDROLYSIS OF SPHINGOMYELINS BY NEUTRAL SPHINGOMYELINASE

β-cell mass is regulated by a balance between β-cell growth and β-cell death, due to apoptosis. We previously reported that apoptosis of INS-1 insulinoma cells due to thapsigargin-induced ER stress was suppressed by inhibition of the Group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)β), associ...

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Bibliographic Details
Main Authors: Lei, Xiao-Yong, Zhang, Sheng, Bohrer, Alan, Bao, Shunzhong, Song, Haowei, Ramanadham, Sasanka
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2530898/
https://ncbi.nlm.nih.gov/pubmed/17685585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700017z
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