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THE GROUP VIA CALCIUM-INDEPENDENT PHOSPHOLIPASE A(2) (iPLA(2)β) PARTICIPATES IN ER STRESS-INDUCED INS-1 INSULINOMA CELL APOPTOSIS BY PROMOTING CERAMIDE GENERATION VIA HYDROLYSIS OF SPHINGOMYELINS BY NEUTRAL SPHINGOMYELINASE
β-cell mass is regulated by a balance between β-cell growth and β-cell death, due to apoptosis. We previously reported that apoptosis of INS-1 insulinoma cells due to thapsigargin-induced ER stress was suppressed by inhibition of the Group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)β), associ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2530898/ https://ncbi.nlm.nih.gov/pubmed/17685585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700017z |
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