Pancreatic Islets and Insulinoma Cells Express a Novel Isoform of Group VIA Phospholipase A(2) (iPLA(2)β) that Participates in Glucose-Stimulated Insulin Secretion and Is Not Produced by Alternate Splicing of the iPLA(2)β Transcript

Many cells express a group VIA 84 kDa phospholipase A(2) (iPLA(2)β) that is sensitive to inhibition by a bromoenol lactone (BEL) suicide substrate. Inhibition of iPLA(2)β in pancreatic islets and insulinoma cells suppresses, and overexpression of iPLA(2)β in INS-1 insulinoma cells amplifies, glucose...

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Hlavní autoři: Ramanadham, Sasanka, Song, Haowei, Hsu, Fong-Fu, Zhang, Sheng, Crankshaw, Mark, Grant, Gregory A., Newgard, Christopher B., Bao, Shunzhong, Ma, Zhongmin, Turk, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716001/
https://ncbi.nlm.nih.gov/pubmed/14636061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi034843p
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