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Calcium-independent Phospholipase A(2) (iPLA(2)β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

Endoplasmic reticulum (ER) stress induces INS-1 cell apoptosis by a pathway involving Ca(2+)-independent phospholipase A(2) (iPLA(2)β)-mediated ceramide generation, but the mechanism by which iPLA(2)β and ceramides contribute to apoptosis is not well understood. We report here that both caspase-12 a...

詳細記述

保存先:
書誌詳細
主要な著者: Lei, Xiaoyong, Zhang, Sheng, Bohrer, Alan, Ramanadham, Sasanka
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596401/
https://ncbi.nlm.nih.gov/pubmed/18936091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807409200
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