Group VIA Phospholipase A(2) (iPLA(2)β) Modulates Bcl-x 5′-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells

Diabetes is a consequence of reduced β-cell function and mass, due to β-cell apoptosis. Endoplasmic reticulum (ER) stress is induced during β-cell apoptosis due to various stimuli, and our work indicates that group VIA phospholipase A(2)β (iPLA(2)β) participates in this process. Delineation of under...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Barbour, Suzanne E., Nguyen, Phuong T., Park, Margaret, Emani, Bhargavi, Lei, Xiaoyong, Kambalapalli, Mamatha, Shultz, Jacqueline C., Wijesinghe, Dayanjan, Chalfant, Charles E., Ramanadham, Sasanka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409262/
https://ncbi.nlm.nih.gov/pubmed/25762722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648956
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