The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates

Mono- and polyubiquitylation of proteins are key steps in a wide range of biological processes. However, the molecular mechanisms that mediate these different events are poorly understood. Here, we employed NMR spectroscopy to map a non-covalent ubiquitin binding surface (UBS) on the Smurf ubiquitin...

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Autors principals: Ogunjimi, Abiodun A., Wiesner, Silke, Briant, Douglas J., Varelas, Xaralabos, Sicheri, Frank, Forman-Kay, Julie, Wrana, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825426/
https://ncbi.nlm.nih.gov/pubmed/20026602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044537
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