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Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
Smad ubiquitination regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that participates in degradation of TGF-β receptors and other targets. Smurf2 WW domains recognize PPXY (PY) motifs on ubiquitin ligase target proteins or on adapters, such as Smad7, that bind to E3 target proteins. We previo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2972958/ https://ncbi.nlm.nih.gov/pubmed/20937913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003023107 |
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