A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling molecules to prevent excessive activation of TGF-β...

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Publicado no:Bone Res
Main Authors: Kushioka, Junichi, Kaito, Takashi, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Chijimatsu, Ryota, Pye, Melanie, Narimatsu, Masahiro, Wrana, Jeffrey L., Inoue, Yasumichi, Ninomiya, Hiroko, Yamamoto, Shin, Saitou, Takashi, Yoshikawa, Hideki, Imamura, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680794/
https://ncbi.nlm.nih.gov/pubmed/33298874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00115-z
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