The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells

Degeneration of the nucleus pulposus (NP) might serve as a trigger for intervertebral disc degeneration (IDD). A recent drug screening study revealed that the thienoindazole derivative, TD-198946, is a novel drug for the treatment of osteoarthritis. Because of the environmental and functional simila...

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Udgivet i:Sci Rep
Main Authors: Kushioka, Junichi, Kaito, Takashi, Chijimatsu, Ryota, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Yano, Fumiko, Saito, Taku, Chung, Ung-il, Tanaka, Sakae, Yoshikawa, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447806/
https://ncbi.nlm.nih.gov/pubmed/32843678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71193-6
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