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Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations
The metal-dependent histone deacetylases (HDACs) catalyze hydrolysis of acetyl groups from acetyllysine side chains and are targets of cancer therapeutics. Two bound monovalent cations (MVCs) of unknown function have been previously observed in crystal structures of HDAC8; site 1 is near the active...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825397/ https://ncbi.nlm.nih.gov/pubmed/20029090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033399 |
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