Targeted mutation of the Hprt gene in mouse embryonic stem cells.
The hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene has been mutated in mouse blastocyst-derived embryonic stem cells by site-directed homologous recombination. Embryonic stem cells were electroporated in the presence of a targeting DNA fragment containing two specific features: (i) The t...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282503/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.22.8583 |
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