Targeted mutation of the Hprt gene in mouse embryonic stem cells.

The hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene has been mutated in mouse blastocyst-derived embryonic stem cells by site-directed homologous recombination. Embryonic stem cells were electroporated in the presence of a targeting DNA fragment containing two specific features: (i) The t...

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-д хэвлэсэн:	Proc Natl Acad Sci U S A
Үндсэн зохиолчид:	Doetschman, T, Maeda, N, Smithies, O
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	National Academy of Sciences 1988
Нөхцлүүд:	Research Article
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282503/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.22.8583
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