Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

We have introduced a 4-bp insertion into the hypoxanthine phosphoribosyltransferase (HPRT) gene of a mouse embryonic stem (ES) cell line by using an "in-out" targeting procedure. During the in step, a homologous integration reaction, we targeted a correcting plasmid to a partially deleted...

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Detaylı Bibliyografya
Asıl Yazarlar: Valancius, V, Smithies, O
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1991
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC369413/
https://ncbi.nlm.nih.gov/pubmed/1996101
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