Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.
We have introduced a 4-bp insertion into the hypoxanthine phosphoribosyltransferase (HPRT) gene of a mouse embryonic stem (ES) cell line by using an "in-out" targeting procedure. During the in step, a homologous integration reaction, we targeted a correcting plasmid to a partially deleted hprt- locu...
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| Pubblicato in: | Mol Cell Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
1991
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369413/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1996101/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.3.1402-1408.1991 |
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