Oncolysis by an HSV-1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma

BACKGROUND: A replication-competent, attenuated, oncolytic herpes simplex virus-1, OncoVEX(GALV/CD), has previously been engineered to express a fusogenic protein from the gibbon ape leukemia virus and cytosine deaminase/uracil phosphoribosyltransferase (CD/UPRT) which converts fluorocytosine (5-FC)...

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Hlavní autoři: Price, Daniel L., Lin, Shu-Fu, Han, Ziqun, Simpson, Guy, Coffin, Robert S., Wong, Joyce, Li, Sen, Fong, Yuman, Wong, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824889/
https://ncbi.nlm.nih.gov/pubmed/20157061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archoto.2009.214
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