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PEGylation of Bacterial Cocaine Esterase for Protection against Protease Digestion and Immunogenicity
Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. A major obstacle to the cli...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824037/ https://ncbi.nlm.nih.gov/pubmed/19857534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.10.015 |
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