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Structural determinants of growth factor binding and specificity by VEGF receptor 2

Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and -3. The extracellular domain of VEGF receptors consists of seven immunoglobulin homology domains, which, upon ligand binding, promote receptor...

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Autors principals: Leppänen, Veli-Matti, Prota, Andrea E., Jeltsch, Michael, Anisimov, Andrey, Kalkkinen, Nisse, Strandin, Tomas, Lankinen, Hilkka, Goldman, Adrian, Ballmer-Hofer, Kurt, Alitalo, Kari
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823880/
https://ncbi.nlm.nih.gov/pubmed/20145116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914318107
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