Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lym...

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Detalles Bibliográficos
Autores principales: Leppänen, Veli-Matti, Tvorogov, Denis, Kisko, Kaisa, Prota, Andrea E., Jeltsch, Michael, Anisimov, Andrey, Markovic-Mueller, Sandra, Stuttfeld, Edward, Goldie, Kenneth N., Ballmer-Hofer, Kurt, Alitalo, Kari
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740881/
https://ncbi.nlm.nih.gov/pubmed/23878260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301415110
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